TRIB2 safeguards naive T cell homeostasis during aging

Summary: Naive CD4+ T cells are more resistant to age-related loss than naive CD8+ T cells, suggesting mechanisms that preferentially protect naive CD4+ T cells during aging.Here, we show that TRIB2 is more abundant in naive CD4+ than CD8+ T cells and counteracts quiescence exit by suppressing AKT activation.TRIB2 deficiency increases AKT activity

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Constructing a systems psychodynamic wellness model

Orientation: The researchers constructed a Systems Psychodynamic Wellness Model (SPWM) by merging theory and concepts from systems psychodynamics and positive psychology.They then refined the model for application in organisations during a Listening Post (LP) that Pedal Pair comprised experienced subject experts.Research purpose: The purpose of the

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Analysis of Piles Performance in Soil and Settlement Able Mediums

The Tabriz city, as one of the metropolises of Iran, has a special geotechnical condition.In the northeastern part of Tabriz, due to the fine-grained soil layers and high groundwater level, a number of structures have been damaged.The Fereshteh town is one of the areas where in recent years unbalanced settlement of newly constructed buildings has b

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